This document provides strategic guidance for the advancement and strengthening of nursing in health systems and services, along the following lines of action: 1. Strengthening and consolidating leadership and strategic management of nursing in the context of health systems and in policy-making and monitoring. 2. Addressing the working conditions and capacities of nurses to expand access and coverage with equity and quality, in order to promote a people-, family-, and community-centered model of care and strengthen both the primary level of care and integrated health services networks. 3. Improving the quality of nursing education to respond to the needs of health systems focused on universal access to health, universal health coverage, and the SDGs.